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Possible reason for Mr. B's warm leg:
Reflex Sympathetic Dystrophy:
Patients with a family history suggestive of germline-susceptibility cancer should be referred for genetic counseling.
Approximately 25% of men with a prostate-specific antigen level between 4 ng/mL and 10 ng/mL and more than 50% of those with a prostate-specific antigen level >10 ng/mL have prostate cancer.
Most patients diagnosed with prostate cancer have no clinical symptoms related to their condition.
Pathologic confirmation is needed to diagnose this condition, and transrectal ultrasound-guided biopsy is a relatively simple office procedure of choice.
Barry MJ. Clinical practice. Prostate-specific-antigen testing for early diagnosis of prostate cancer. N Engl J Med. 2001;344:1373-7. [PMID: 11333995] [PubMed]
Screening with digital rectal examination or prostate-specific antigen measurement has not been shown to decrease prostate cancer mortality rates in controlled trials and will result in an increase, rather than a decrease, in cancer incidence.
D’Amico AV, Barry MJ. Prostate cancer prevention and finasteride. J Urol. 2006;176:2010-2; discussion 2012-3.[PMID: 17070238] [PubMed]

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