Pharm and OD


Relaxants (so that one needs not move):
- orphenadrine (Norflex)
- cyclobenzaprine (Flexeril)

Fluoxetine is an SSRI & has no effect on the NE system and so does not produced the SEs common to TCAs (anticholinergic SEs = cardiac conduction disturbances, constipation, drowsiness, dry mouth,   and orthostatic hypotension). Unlike TCAs, however, SSRI do cause loss of appetite !  REF

FA2020: BBs an are antidote to theophylline b/c they decrease cAMP, theo increases cAMP.

Carvedilol is propranolol with alpha-1 blocking added.  They are both non-selective BBs. (wikipedia).

The 1/2 life of epinephrine is 2 min and it is eliminated via kidneys. (MedStudy Immunology).

The intravenous dose of Morphine should be 1/3 the oral dose when going from PO to IV.  REF

What is the mechanism of action of colchicine in gout ? REF

What are the two causes of QRS widening in cocaine toxicity ? What drug do you never use ? REF

Drugs which have the opposite effect on receptors common to them both.

Ipratropium - Methacholine.
- Ipratropium - M3 receptor antagonist preventing bronchoconstriction.
- Methacholine - M3 receptor agonist used in asthma challenge tests.

Oxybutynin - Bethanechol
- Oxybutynin - M1, M2, M3 antagonist.
- Bethanechol - Selective M receptor agonist.

Metformin's MC SE are diarrhea, abdominal pain, nausea and bloating.

How to distinguish anticholinergics from sympathomimetics ? Diaphoresis in sympathomimetics.



Attachment Below: ECG Findings and Treatments for Common Toxins and Drug Overdoses

Recognition and Management of Acute Medication Poisoning REF
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Marc Curvin,
Jun 9, 2013, 5:14 PM
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