Sympathomimetics

Sympathomimetic decongestants such as pseudoephedrine and phenylephrine can be problematic in elderly patients because they can:   (check one)
A. decrease blood pressure
B. cause bradycardia
C. worsen existing urinary obstruction
D. enhance the anticholinergic effects of other medications
E. enhance the sedative effects of other medications

Correct.

Sympathomimetic agents can elevate blood pressure and intraocular pressure, may worsen existing urinary obstruction, and adversely interact with  -blockers, methyldopa, tricyclic antidepressants, and oral hypoglycemic agents and MAOIs. They also speed up the heart rate. First-generation nonprescription antihistamines can enhance the anticholinergic and sedative effects of other medications.
 
Ref: Brunton LL (ed): Goodman & Gilman's The Pharmacological Basis of Therapeutics, ed 11. McGraw-Hill, 2006, pp 254, 260, 262. 2) Young SS: Appropriate Use of Common OTC Analgesics and Cough and Cold Medications. American Academy of Family Physicians monograph, 2008.

For which of the following reasons are tricyclic antidepressants considered second-line therapies for terminally ill patients with depression? REF

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